Abicipar pegol: the non-monoclonal antibody anti-VEGF

Development of a Novel Inhibitory Chimeric Anti-HER2 Monoclonal Antibody

Clinical trials referral resource: Current clinical trials of the anti-VEGF monoclonal antibody bevacizumab.

Given the well-established role of angiogenesis (or new blood vessel formation) in tumor growth and metastasis, antiangiogenic therapy, a concept first proposed by Dr. Judah Folkman,[1] has become increasingly recognized as a promising new anticancer strategy. As the angiogenic switch in tumors reflects the net balance of a diverse group of endogenous angiogenic promoters and inhibitors, a mult...

Mouse Anti-Tetracycline Monoclonal Antibody

Product Overview: Mouse monoclonal antibody to tetracycline. Immunogen: Tetracycline-KLH Conjugate Clone: K88Y88 Host animal: Mouse Source: Mouse Ascites Purity: Protein A Affinity Chromatography. Buffer: 0.01 moL/L pH 7.4 Phosphate Buffer Solution. Protein Content: 1 mg/mL Appearance: Clear Colorless Solution Introduction: Tetracycline is a broad-spectrum polyketide antibiotic produced by the ...

A Humanized Anti-VEGF Rabbit Monoclonal Antibody Inhibits Angiogenesis and Blocks Tumor Growth in Xenograft Models

Rabbit antibodies have been widely used in research and diagnostics due to their high antigen specificity and affinity. Though these properties are also highly desirable for therapeutic applications, rabbit antibodies have remained untapped for human disease therapy. To evaluate the therapeutic potential of rabbit monoclonal antibodies (RabMAbs), we generated a panel of neutralizing RabMAbs aga...

Developing a Noninvasive Procedure Using Labeled Monoclonal Antibody Anti-VEGF (Bevacizumab) for Detection of Endometriosis

The off-label use of bevacizumab labeled with 99mTc as a new radiopharmaceutical for imaging of endometriosis is a promising noninvasive, new clinical procedure. The bevacizumab in monoclonal antibodies targeted at vascular endothelial growth factor (VEGF) is superexpressed in cases of endometriosis. In this study we evaluate the imaging of endometriosis lesion in rats (induced to endometriosis...